Family: Poisoning disease
Symptoms: decreased appetite and vomiting
Inhibiting prostaglandin synthesis, high-dose aspirin can prevent the process of oxidative phosphorylation, but it may also cause high blood sugar. Sick dogs are excited to breathe in the early stage of illness, and then turn to suppressed breathing in the later stage. Symptoms of metabolic acidosis, decreased platelet aggregation, and blocked bone marrow development may occur.
Accidental swallowing of aspirin (acetylsalicylic acid) or improper dose of medication. Puppies are prone to this disease due to the lack of metabolic enzymes in their bodies, especially the enzymes that synthesize glucoside. A dose of more than 60 mg/kg for sick dogs can cause poisoning.
The main symptoms
Shortness of breath occurs in the early stage of poisoning, and breathing is inhibited in the later stage; symptoms such as increased body temperature, decreased appetite, vomiting, ulcerative enteritis, metabolic acidosis, etc. may occur. In severe cases, symptoms such as coma, impaired kidney function, and bleeding may occur. Cause non-regenerative anemia in dogs; occasionally convulsions.
Diagnosis and understanding of the medical history is very useful for the diagnosis of this disease; metabolic acidosis, uric acid, anion gap enlargement; salicylic acid content in serum or urine has a certain diagnostic significance, take 1ml urine, add 3 drops of 10% chlorine after acidification Iron, red, indicating positive salicylic acid; should be distinguished from other diseases that cause gastritis and severe metabolic acidosis, ethylene glycol poisoning, and other non-steroidal antibacterial anti-inflammatory drugs, such as ibuprofen poisoning.
Animals ingesting aspirin should induce vomiting, gastric lavage, activated charcoal and catharsis drugs as soon as possible to prevent further absorption of the poison; alkalization of urine for 36～48h to promote the discharge of poison: sodium bicarbonate, 50 mg/kg, oral, 2～3 per day Time; Sodium bicarbonate can also alleviate the body's metabolic acidosis. Supportive therapy: fluid replacement, electrolyte supplementation, maintenance of acid-base balance; application of gastrointestinal protectors and histamine receptor antagonists (cytidine, methamphetamine); in severe cases, alkaline peritoneal dialyzate dialysis.